![]() In addition, the proportion of accumulated B cells can differentiate into stromal plasma cells (plasma cells) (ESPC). Such immune responses distort the microenvironment in the endometrium, cause the migration of circulating B cells into the endometrial stroma and the deposition of these lymphocytes in the lumen of the glands. Microbial infection of the endometrium or dysbiosis leads to abnormal expression of pro-inflammatory molecules and causes unusual local immune responses. Scientists consider infection only a trigger of a complex sequence. Patients with miscarriage in early pregnancy.Ĭhronic endometritis is associated with qualitative and quantitative changes in the endometrial microbiome: the abnormal reproduction of various types of microorganisms, mainly gram-negative and intracellular bacteria (eg Enterococcus faecalis, mycoplasma, ureaplasma, chlamydia, and Streptococcus).Įvidence of the infectious origin of chronic endometritis is the effectiveness of antibiotics in this pathology. Logically, the question arises: should all patients be examined for chronic endometritis?ĭefinitely need to be examined for chronic endometritis:Īll women with suspected endometrial polyps Women of childbearing age with chronic endometritis have a 60% higher risk of future infertility (Wiesenfeldetal., 2012 level of evidence 2b). We emphasize that in women with endometrial polyps, the prevalence of chronic endometritis increases significantly (Pereletal., 2019 level of evidence 2b). Moreover, the prevalence of pathology in these women is twice as high as in fertile women (Liuetal., 2018 level of evidence 2b) and higher than the population average (Puenteetal., 2020). This affects fertility and promotes pain during menstruation and pelvic pain (Coughlanetal., 2014).Īccording to statistics, 56.8% of patients with infertility (Cicinellietal., 2015) are diagnosed with chronic endometritis. The presence of chronic provokes changes in the contractile capacity of the uterus. Repeated implantation failures (RIF) – two or more negative attempts to transfer good quality embryos – blastocyst (Bouetetal., 2016 Cicinellietal., 2005 Johnston-MacAnannyetal., 2011 Songetal., 2018 Tersoglioetal., 2015 Jan et al. Recurrent miscarriages (Kitaya, 2011 McQueenetal., 2005 Zolghadri et al., 2011) Idiopathic infertility – infertility of uncertain origin (Cicinellietal., 2018 Liuetal., 2018), The diagnosis was found to be closely related to: Reproductologists were the first to talk about the importance of diagnosing chronic endometritis. He was treated as a kind of ghost diagnosis. Therefore, chronic endometritis in gynecology was not given much importance. The problem is that patients may not be aware of the pathology for years, which does not manifest itself in any way.Īccording to the literature – 25% of cases of chronic endometritis are asymptomatic!Įven in the presence of complaints, clinical symptoms are nonspecific (Romeroetal., 2004), similar to other diseases. ![]() ![]() Until 10 years ago, gynecologists were not wary of chronic endometritis. Signs of any inflammatory process described before our era are:Įxperts consider chronic endometritis as a persistent inflammation of the uterine mucosa, characterized by superficial endometrial edema, high stromal cell density, dissociated maturation between the epithelium and stroma, and infiltration of endometrial stromal plasma cells. Chronic endometritis can be described in one word – inflammation. ![]()
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